Purpose

Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 59 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Body mass index 40-55 kg/m2 - Age less than 60 years - Available support person - Adequate insurance - All other criteria required for renal transplantation

Exclusion Criteria

  • Schizophrenia - Bipolar disorder - Crohn's disease - Human Immunodeficiency Virus - Cirrhosis - Prior weight loss surgery - Prior mesh hernia repair - Prior anti-reflux surgery - Inability to walk 200 feet - Significant coronary disease - Significant lung disease - Fixed expiratory volume 1 less than 75% or on oxygen - Addiction to alcohol or drugs - Inability to quit smoking - Jehovah's witness - Non-compliance with dialysis regimen - Previous renal transplant - Non-English speaking

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Surgical Gastric Bypass
Patients will undergo surgical gastric bypass according to standard institutional protocols
  • Procedure: Gastric Bypass
Experimental
Medical Weight Loss Management
Patients will receive best practices medical management for weight loss under current institutional protocols
  • Other: Weight Loss Program

More Details

Status
Active, not recruiting
Sponsor
Vanderbilt University Medical Center

Study Contact

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.