Purpose

This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? Patients with TS, patients with OCD, and healthy controls will complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and quality of life.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

for the patient groups:

- age 18 years or older

- previous diagnosis of Tourette syndrome and/or obsessive compulsive disorder

Exclusion Criteria

for the patient groups:

- none

Inclusion criteria for healthy controls includes:

- 18 years of age or older

Exclusion criteria for the patient groups:

- history of any neurologic or psychiatric diagnoses

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Cross-Sectional

Arm Groups

ArmDescriptionAssigned Intervention
Tourette Syndrome Individuals previously diagnosed with Tourette syndrome (TS). Participants must be 18 years of age or older.
  • Other: None - observational study
    None - observational study
Obsessive Compulsive Disorder Individuals previously diagnosed with obsessive compulsive disorder (OCD). Participants must be 18 years of age or older.
  • Other: None - observational study
    None - observational study
Healthy Controls Individuals with no past or current neurologic or psychiatric illness. Participants must be 18 years of age or older.
  • Other: None - observational study
    None - observational study

Recruiting Locations

Vanderbilt University Medical Center
Nashville, Tennessee 37232-5400
Contact:
Chelsea Mundy
615-936-2025
chelsea.e.mundy@vumc.org

More Details

Status
Recruiting
Sponsor
Vanderbilt University Medical Center

Study Contact

Chelsea Mundy
+1 (615) 936-2025
chelsea.e.mundy@vumc.org

Detailed Description

Tourette syndrome (TS) is a neurodevelopmental disorder affecting 1% of school-aged children, with one-third of patients suffering persistent tics into adulthood. Obsessive-compulsive disorder (OCD) is a common comorbidity with TS. Individuals with either TS or OCD frequently exhibit sensory dysregulation, manifesting as heightened awareness of internal and external stimuli. For patients with OCD, sensory dysregulation has been linked to obsessive-compulsive symptoms and is an important consideration in treatment strategies. Sensory dysregulation remains largely unexplored in TS, but preliminary data suggests it is dissociable from tics, linked with obsessive-compulsive symptoms, and associated with poorer quality of life (QOL). This study seeks to address two key questions related to sensory dysregulation in TS and OCD: 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? To do so, we will recruit patients with TS, patients with OCD, and healthy controls to complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and QOL. Addressing these knowledge gaps will enhance our understanding of bothersome sensory symptoms in TS and OCD, shed light on clinical overlap and/or distinctions between these commonly co-occurring psychiatric diagnoses, and clarify QOL impact and the potential need for more direct targeting of these symptoms.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.