Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup
Purpose
Study of the palatability and acceptability of dexamethasone oral tablets crushed and placed in apple sauce or pudding in comparison with the IV solution mixed with sugar syrup and given orally. It is hypothesized that dexamethasone tablets crushed and administered in apple sauce or pudding will be more palatable and acceptable for pediatric patients receiving dexamethasone for an acute asthma exacerbation or croup.
Conditions
- Asthma
- Croup
Eligibility
- Eligible Ages
- Between 1 Year and 7 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Diagnosis of acute asthma exacerbation or croup (laryngotracheitis) in the Vanderbilt Children's Hospital Emergency Department - Age 1 to 7 years - Dexamethasone treatment indicated - No other acute or chronic process accounting for signs and symptoms (e.g., foreign body aspiration, pneumonia, cystic fibrosis) - Have not received systemic corticosteroid for current episode prior to enrollment
Exclusion Criteria
- Allergy to dexamethasone or apple sauce and pudding - Unable to take medication orally
Study Design
- Phase
- Phase 4
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Dexamethasone IV for PO |
Dexamethasone IV for PO solution mixed with sugar syrup to be given orally |
|
|
Active Comparator Dexamethasone crushed tablets |
Dexamethasone tablet crushed and placed in apple sauce or pudding to be given orally |
|
More Details
- Status
- Terminated
- Sponsor
- Vanderbilt University Medical Center