Genetics of Appendix Cancer Study
Purpose
The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.
Conditions
- Appendix Cancer
- Appendiceal Cancer
- Appendiceal Neoplasms
- Appendiceal Mucinous Neoplasm
- Appendiceal Adenocarcinoma
- Appendiceal Carcinoid Tumor
- Appendiceal Neoplasm Malignant Secondary
- Appendix Adenocarcinoma
- Appendix Mucinous Neoplasm
- Appendix Tumor
- Appendix Cancer Metastatic
- Appendix NET
- Low-Grade Appendix Mucinous Neoplasm
- High Grade Appendix Mucinous Neoplasm
- High Grade Appendix Mucinous Adenocarcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
GAP Social - Known diagnosis of appendix cancer in the United States - Mentally and physically able to consent and participate in the study GAP Vanderbilt - Known diagnosis of appendix cancer - Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study - Mentally and physically able to consent and participate in the study GAP Parent - Biological parents (mother and/or father) of individuals actively participating in the GAP Study - Residing in the United States - Mentally and physically able to consent and participate in the study
Exclusion Criteria
- Women pregnant at the time of consent - Prisoners - Unable to provide informed consent - Unable to read, write, or complete questionnaires in English
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| GAP Social | Individuals ages 18+ years with an appendix cancer diagnosis in the United States. |
|
| GAP Vanderbilt | Individuals ages 18+ years with an appendix cancer diagnosis seen at Vanderbilt. |
|
| GAP Parent | Biological parents of active GAP (Social and Vanderbilt) Study participants. |
|
Recruiting Locations
Nashville, Tennessee 37232
More Details
- Status
- Recruiting
- Sponsor
- Andreana Holowatyj, PhD, MSCI
Detailed Description
The Genetics of Appendix Cancer (GAP) Study aims to analyze hereditary factors, tumor characteristics and clinical features/outcomes among adults diagnosed with appendix cancer and their biological parents. Patients are recruited at any time after a diagnosis of appendix cancer and followed for up to 6 years after study enrollment. This cohort is enriched by robust biospecimens and data collections.