Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
Purpose
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Condition
- Parkinson Disease
Eligibility
- Eligible Ages
- Over 40 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1) - Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2) - Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist - Age at least 18 - Able to participate in intraoperative testing - English speaking
Exclusion Criteria
- Age less than 18 - Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Sequential Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Determination of DLPFC neurophysiology biomarkers of DBS associated cognitive impairment |
Neurophysiology recordings will be performed from dorsolateral prefrontal cortex (DLPFC) during deep brain stimulation surgery, with and without STN or GPI stimulation, at rest and during a working memory task. |
|
|
Experimental Neurophysiology biomarkers of DBS mediated cognitive impairment following chronic stimulation |
Neurophysiology recordings will be performed from subthalamic nucleus (STN) or globus pallidus internus (GPI) with stimulation on and off, at rest and during a working memory task, in patients who have previously been implanted with DBS and have implantable pulse generators capable of recording local field potentials. |
|
Recruiting Locations
Nashville, Tennessee 37232
More Details
- Status
- Recruiting
- Sponsor
- Vanderbilt University Medical Center