Vanderbilt Clinical Trials

At least one of the following three options for aortic stenosis and/or the single option for mitral regurgitation are determined from echocardiogram findings: 1. AVA or DVI (Patients with either AVA or DVI measured in their echo) 1. AVA ≤ 1.0 cm2 2. OR Dimensionless index ≤ 0.25 2. AVA + OTHER (Patients with AVA and at least 1 other echo measurement in their echo) 1. AVA ≤ 1.2 cm2 AND 2. Mean Gradient ≥ 40 mmHg OR 3. Peak Gradient ≥ 64 mmHg OR 4. Peak Velocity ≥ 4.0 m/s 3. POSSIBLE (Possible Aortic Stenosis but AVA is not measured) 1. AVA is missing AND 2. Mean Gradient ≥ 40 mmHg OR 3. Peak Gradient ≥ 64 mmHg OR 4. Peak Velocity ≥ 4.0 m/s Any patient flagged for "POSSIBLE" does not result in automatically alerting the clinician, instead a notification is sent to the Tempus research team for manual review in conjunction with the site PI and if requested by Tempus or site PI, a Steering Committee member. If clinical confirmation is received for severe aortic stenosis from the site PI, an alert is sent to the clinician. 1. Mitral Regurgitation a. Mention of severe mitral regurgitation or moderate-severe mitral regurgitation Any patient mentioned with only moderate MR or a lesser severity will be excluded.

1. Age < 18 years 2. Patient had evidence of a prior transcatheter or surgical repair or replacement of the target valve 3. The echocardiogram was ordered by a cardiologist on the MHT or a cardiac surgeon 4. Patient already has a scheduled clinic visit with a member of the MHT or a recent (within 1 year) clinic visit with the MHT, or a scheduled transcatheter or surgical procedure in the future.