Swallowing Impairments in Adults With and Without Alzheimer's Disease

Purpose

This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease. Healthy adults and individuals with Alzheimer's disease will: - undergo tests of cough and swallow function - undergo tests of grip and tongue strength - complete questionnaires Caregivers of individuals with Alzheimer's disease will also complete questionnaires.

Conditions

  • Alzheimer Disease
  • Caregiver Burden
  • Healthy Aging
  • Dysphagia

Eligibility

Eligible Ages
Over 60 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

for AD cohort: 1. adult ≥60 years old 2. diagnosis of AD by a neurologist (confirmed with imaging, spinal tap, behavioral testing) 3. no prior history of other neurological diseases 4. no prior history of respiratory diseases 5. no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region 6. consuming some form of oral intake 7. able to follow basic directions 8. able/willing to provide consent/assent.

Exclusion Criteria

for AD Cohort: 1. individual <60 years old 2. Diagnosis of another type of dementia 3. History of neurological/respiratory diseases 4. History of head and neck surgery/head and neck cancer/radiation to head and neck region 5. not consuming any oral intake 6. Unable to follow basic directions 7. Unable to provide consent based on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC), score <15 OR provide assent and a legal guardian provides consent. Inclusion criteria for care partners of individuals with AD will be: 1. care partner of an individual with AD 2. willing to complete questionnaires/participate in an interview. Exclusion Criteria for Caregivers of Individuals with AD: 1. not the primary caregiver of an individual with AD 2. unwilling to complete questionnaires/semi-structured interview Inclusion criteria for community-dwelling adults will be: 1. adult ≥60 years old 2. no prior history of neurological diseases or respiratory diseases 3. no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region 4. no prior history of swallowing difficulties based on participant report. 5. Score ≥26 on the Montreal Cognitive Assessment (MOCA) Exclusion Criteria for Healthy Cohort: 1. individual <60 years old 2. history of neurological disease 3. history of respiratory disease 4. history of head and neck surgery/head and neck cancer/radiation to head and neck region 5. history of swallowing difficulties 6. Score <26 on the Montreal Cognitive Assessment (MOCA)

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Healthy community dwelling adults Healthy adults ≥ 60 years old with no prior history of neurological or respiratory diseases, swallowing impairments, or history of head and neck surgery, cancer, or radiation to the head or neck will be enrolled in this study.
Adults with Alzheimer's Disease and their caregivers Adults with a diagnosis of Alzheimer's disease and their caregivers will be enrolled in this study.

Recruiting Locations

Vanderbilt University Medical Center
Nashville, Tennessee 37232
Contact:
Cara Donohue, PhD CCC-SLP
615-852-5085
cara.donohue@vumc.org

More Details

Status
Recruiting
Sponsor
Vanderbilt University Medical Center

Study Contact

Cara Donohue, PhD CCC-SLP
615-852-5085
cara.donohue@vumc.org

Detailed Description

This study will involve one in-person research visit that will last approximately 1-1.5 hours and will consist of a screening, cough testing, swallow function testing, assessments of hand grip and tongue strength, and completion of questionnaires. Caregivers of those with Alzheimer's disease will also complete questionnaires.