Purpose

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.

Condition

Eligibility

Eligible Ages
Between 18 Years and 120 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Diagnosis of non-small cell lung cancer
  • Clinical stage I and II disease
  • Resectable disease and complete surgical resection planned
  • Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network
  • Tumor specimen samples must be available at resection

Exclusion Criteria

  • Chemotherapy before surgery
  • Radiotherapy before surgery

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Resectable non-small cell lung cancer Patients with clinical stage I or II invasive lung cancer that can be completely removed by surgery and who have not undergone chemotherapy or radiotherapy before surgery
  • Genetic: gene expression analysis
    Blood and lung tissue collection
  • Genetic: microarray analysis
    Blood and lung tissue collection
  • Genetic: protein expression analysis
    Blood and lung tissue collection
  • Other: biologic sample preservation procedure
    Blood and lung tissue collection
  • Other: laboratory biomarker analysis
    Blood and lung tissue collection
  • Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry
    Blood and lung tissue collection

Recruiting Locations

Vanderbilt-Ingram Cancer Center
Nashville, Tennessee 37232-6838
Contact:
Clinical Trials Office - Vanderbilt-Ingram Cancer Center
800-811-8480

More Details

NCT ID
NCT00897117
Status
Recruiting
Sponsor
Vanderbilt-Ingram Cancer Center

Study Contact

VICC Clinical Trials Information Program
800-811-8480

Detailed Description

OBJECTIVES:

- Develop statistical and computational methods for modeling the relationships between multiple variable protein and RNA expression data and clinical endpoints using both supervised and unsupervised classification and pattern recognition approaches.

- Determine protein and RNA expression fingerprints on completely resected non-small cell lung cancer without prior chemotherapy.

- Correlate protein and RNA expression fingerprints with T-stage and nodal involvement at the time of surgery, and collect outcome data to allow correlation with recurrence (local and/or distant) and survival.

OUTLINE: This is a multicenter study.

Any excess tissues removed from surgery and would otherwise be discarded (tissues not used for diagnosis and/or treatment decision making) are obtained for this study. Tissue are analyzed for molecular features that predict biologic behavior. Quantitation of RNA, gene expression profiles, and protein expression patterns are assessed by matrix-assisted laser desorption/ionization time of flight mass spectroscopy and microarray analysis.

Medical records are reviewed to obtain information about results of tests associated with cancer diagnosis. Further progress in cancer treatment and tumor behavior after surgery are followed via record review.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.