Nashville Early Diagnosis Lung Cancer Project
This screening study will address the lack of molecular strategies for the early detection of lung cancer and integrate those with epidemiological and imaging strategies. The hypothesis is that the repeated measure of biomarkers of risk obtained from the molecular analysis of biological specimens including those from bronchoscopy (bronchial brushings and biopsies) may contribute to the refinement of high-risk populations and allow an earlier clinical diagnosis. The goal of the investigators study is to provide screening for lung cancer in a high-risk population. In this prospective cohort it will be tested whether repeated measure of biomarkers of risk allows early detection of lung cancer.
- Lung Cancer
- Eligible Ages
- Between 55 Years and 80 Years
- Eligible Genders
- Accepts Healthy Volunteers
- 55 - 80 years of age - Current smoker or former smoker. If former smoker, must have quit smoking less than 15 years ago - >/= 30 pack year of smoking history
- History of diagnosis/treatment of lung cancer in the past 2 years - History of head/neck or esophageal cancer in the last 1 year - Inability to provide informed consent - Participants in whom stopping anti-platelet or anti-coagulation therapy would have an adverse effect (DVT, mechanical heart valves, unstable coronary syndrome, etc.)
- Study Type
- Observational Model
- Time Perspective
|Screening||These high-risk subjects will undergo screening for lung cancer. All subjects will undergo all listed interventions||
- Vanderbilt-Ingram Cancer Center
Study ContactVanderbilt-Ingram Service for Timely Access
It is proposed to test the hypotheses in a screening study of high risk individuals (characterized by an established prediction rule). The expected prevalence of lung cancer in this high risk group is estimated to be 2% per year. All individuals benefit from clinic visit, low-dose Chest CT, spirometry and auto-fluorescence bronchoscopy at baseline, Chest CT, follow-up doctor visit, and auto-fluorescence bronchoscopy at least at year 2 and 5.