Nashville Early Diagnosis Lung Cancer Project
This screening study will address the lack of molecular strategies for the early detection of lung cancer and integrate those with epidemiological and imaging strategies. The hypothesis is that the repeated measure of biomarkers of risk obtained from the molecular analysis of biological specimens including those from bronchoscopy (bronchial brushings and biopsies) may contribute to the refinement of high-risk populations and allow an earlier clinical diagnosis. The goal of the investigators study is to provide screening for lung cancer in a high-risk population. In this prospective cohort it will be tested whether repeated measure of biomarkers of risk allows early detection of lung cancer.
- Lung Cancer
- Eligible Ages
- Between 50 Years and 79 Years
- Eligible Genders
- Accepts Healthy Volunteers
- 50 - 79 years of age, Current smoker with at least 25 years of smoking, at least 10 cigarettes/day, or former smoker at least 20 PKY history of cigarette smoking total, who quit 20 years ago or less
- 6 year risk of ≥2.5% using Tammemagi Lung Cancer Risk Prediction Calculator: www.brocku.ca/cancerpredictionresearch
- History of diagnosis/treatment of lung cancer in the past 2 years or of head/neck or esophageal cancer in the last 1 year.
- Inability to provide informed consent
- Study Type
- Observational Model
- Time Perspective
|Screening||These high-risk subjects will undergo screening for lung cancer. All subjects will undergo all listed interventions||
- NCT ID
- Vanderbilt-Ingram Cancer Center
Study ContactVICC Clinical Trials Information Program
It is proposed to test the hypotheses in a screening study of high risk individuals (characterized by an established prediction rule). The expected prevalence of lung cancer in this high risk group is estimated to be 2% per year. All individuals benefit from clinic visit, low-dose Chest CT, spirometry and auto-fluorescence bronchoscopy at baseline, Chest CT, follow-up doctor visit, and auto-fluorescence bronchoscopy at least at year 2 and 5.