Vanderbilt Clinical Trials

Eligibility

Eligible Ages

Between 8 Years and 20 Years

Eligible Genders

All

Accepts Healthy Volunteers

Yes

Criteria

Inclusion Criteria:

This study will be open to all English speakers who meet eligibility criteria regardless
of race, gender, minority or socioeconomic status. Inclusion criteria to be met are
listed below:

1. Individuals ages 8-20 (all participants)

2. Documented NF-1 (NF patients only)

3. If female, participant is post-menarche (NF patients only)

4. If male, participant has reached Tanner Stage 2 (NF patients only)

5. Participant able to swallow capsule (NF patients only, may be confirmed via
swallowability test, described below)

6. Participant's English is sufficient for school (all participants)

7. Participant must either answer "yes" to question A, or answer "yes" to at least 2
items for questions B-D listed below:

A. Has your child ever been diagnosed with a reading disability? B. Did your child have
trouble learning how to "sound out" words? C. Have you (parent) ever been concerned about
your child's reading ability? D. Did the school or teacher ever express any concerns
about your child's reading ability? Swallowability Assessment: We may ask patients to
perform a capsule swallowability assessment prior to enrollment. We will ask subjects to
attempt to swallow an empty capsule, matching the same size of the Lovastatin 20mg and
40mg capsules to be used in the study, to confirm swallowability. Patients will be
provided with up to 2 capsules as needed to successfully perform the swallowability
assessment. If the patient is unable to swallow the capsule, enrollment in the study may
deferred or declined.

A child will be excluded if he/she meets any of the following criteria, which will be
determined by initial telephone screening as well as review of medical/developmental
history prior to and during testing:

1. Child 7 years of age or less;

2. known uncorrectable visual impairment;

3. documented hearing impairment greater than or equal to a 25 dB loss;

4. medical contraindication to MRI procedures (e.g., metal devices);

5. any psychiatric, behavioral, or developmental disorder that would preclude active
participation in in-depth tutoring sessions

6. Pregnant at time of screening.

7. Known conditions which are contraindicated to Lovastatin

1. Hypersensitivity to the medication

2. Uncontrolled Epilepsy

3. Metabolic Syndrome X, High Blood Sugar,

4. Muscle Damage Due to Autoimmunity

5. Stroke caused by Bleeding in the Brain, Loss of Memory,

6. Severely Low Blood Pressure

7. Liver Problems including Abnormal Liver Function Tests

8. Severe Renal Impairment,

9. Serious Muscle Damage that may Lead to Kidney Failure,

10. Recent Operation or significant Injury

11. Muscle Pain or Tenderness with Increase Creatinine Kinase,

12. Habit of Drinking Too Much Alcohol

13. Pregnant or lactating. - Lovastatin is contraindicated during pregnancy and in
nursing mothers because it decreases synthesis of cholesterol and other
products of the cholesterol biosynthesis pathway that are essential components
for fetal development.

Children who meet criteria for ADHD, Oppositional Defiant Disorder, adjustment disorder,
and/or mild depression will be eligible as long as they are not taking psychotropic
medications, with the exception of stimulant medication for ADHD.

For pilot participants only:

Criteria for inclusion/exclusion for pilot participants is outlined below. Children who
meet criteria for ADHD, Oppositional Defiant Disorder, adjustment disorder, and/or mild
depression will be eligible as long as they are not taking psychotropic medications, with
the exception of stimulant medication for ADHD.

1. Children ages 8-17

2. Participant is a native English speaker

3. Participant must either answer "yes" to question A, or answer "yes" to at least 2
items for questions 2-4 listed below:

A. Has your child ever been diagnosed with a reading disability? B. Did your child have
trouble learning how to "sound out" words? C. Have you (parent) ever been concerned about
your child's reading ability? D. Did the school or teacher ever express any concerns
about your child's reading ability?

A child will be excluded if he/she meets any of the following criteria, which will be
determined by initial telephone screening as well as review of medical/developmental
history prior to and during testing:

1. Children 7 years of age or younger

2. previous diagnosis of Intellectual Disability;

3. known uncorrectable visual impairment;

4. documented hearing impairment greater than or equal to a 25 dB loss;

5. medical contraindication to MRI procedures (e.g., metal devices);

6. known IQ below 70;

7. a pervasive developmental disorder; and

8. any known neurologic pathology, including epilepsy, spina bifida, cerebral palsy,
traumatic brain injury, optic gliomas, and brain tumors (other than UBOs).

9. Comorbid severe psychiatric disorders will also be excluded.