Vanderbilt Clinical Trials

Patient Satisfaction and Postoperative Analgesia Between Subarachnoid Block With 2-chloroprocaine Versus General Anesthesia for Knee Arthroscopy

Purpose

The study evaluates the efficacy of two different anesthetic techniques in patients undergoing unilateral knee arthroscopy. Participants will be randomized to receive either subarachnoid block with 2-chloroprocaine or general anesthesia plus intravenous fentanyl.

Conditions

Knee Arthroscopy
General Anesthesia
Subarachnoid Block

Eligibility

Eligible Ages: Between 30 Years and 65 Years
Eligible Genders: All
Accepts Healthy Volunteers: No

Inclusion Criteria

Patients with ASA physical status classification of I, II, or III - Patients without a current diagnosis of chronic pain or chronic opioid use for > 1-month prior to knee arthroscopy - Patients who are scheduled to undergo unilateral knee arthroscopy - Patients do not have a contraindication to receiving regional anesthesia

Exclusion Criteria

Preexisting sensory or motor deficit in operative extremity - Patients with a contraindication to general anesthesia - Patient undergoing meniscal or ligamentous repair

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Randomized
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
Masking: None (Open Label)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Subarachnoid block		Procedure: Subarachnoid block Neuraxial anesthesia will be performed at the L2-3 or L3-4 interspace with a 25-gauge Whitacre needle in the sitting position. After free flow of cerebrospinal fluid (CSF), 40-45mg of 2-chloroprocaine will be injected based on patient's height and discretion of attending anesthesiologist, needle withdrawn and the patient placed supine.
Active Comparator General anesthesia		Procedure: General anesthesia General anesthesia will be delivered per standard procedure. General anesthesia will include induction with propofol 1-3mg/kg followed by placement of a laryngeal mask airway with maintenance anesthesia of sevoflurane 0.5-1 minimum alveolar concentration (MAC).

More Details

Status: Terminated
Sponsor: Vanderbilt University Medical Center

Study Contact

Detailed Description

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.