Vanderbilt Clinical Trials

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Purpose

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Condition

Parkinson Disease

Eligibility

Eligible Ages: Over 40 Years
Eligible Genders: All
Accepts Healthy Volunteers: No

Inclusion Criteria

Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center - Planned clinical electrode trajectory that contacts caudate - Age greater than or equal to 40 - Diagnosis of Parkinson's disease - Able to participate in intraoperative testing - English speaking

Exclusion Criteria

Age less than 40 - Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions) - Movement disorder other than Parkinson's disease

Study Design

Phase: N/A
Study Type: Interventional
Allocation: N/A
Intervention Model: Single Group Assignment
Primary Purpose: Basic Science
Masking: None (Open Label)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Neural recordings and stimulation		Other: Neurophysiology recordings Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a working memory task evaluated Procedure: Neural stimulation Neural stimulation will be delivered during a working memory task and its impact on task performance quantified

Recruiting Locations

Vanderbilt University Medical Center
Nashville, Tennessee 37232

Contact:
Sarah K Bick, MD

More Details

Status: Recruiting
Sponsor: Vanderbilt University Medical Center

Study Contact

Sarah Bick, MD
615-322-1883
Sarah.Bick@vumc.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.