Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells
Purpose
The purpose of this study is to understand how cells of the immune system use the common sugar glucose to fuel energy production and as a building block within the cell. Investigators will intravenously infuse a non-radioactive glucose tracer into participants over a few hours and collect immune cells from the blood to track uptake and usage of this glucose within these immune cells.
Conditions
- Glucose
- Metabolism
- Isotope Labeling
- Immune System and Related Disorders
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Adults aged 18 or older
Exclusion Criteria
- Pregnant - Prisoner or in police custody - Uncontrolled hyperglycemia/diabetes - Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500cc in an 8 week period - Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, that might interfere with the study objectives - Any reason which, in the opinion of the study investigator, adds additional risk to the participant
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Other 13C6-Glucose |
10-25gm of 13C6-Glucose |
|
Recruiting Locations
Vanderbilt University Medical Center
Nashville 4644585, Tennessee 4662168 37212
Nashville 4644585, Tennessee 4662168 37212
More Details
- Status
- Recruiting
- Sponsor
- Vanderbilt University Medical Center