A Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer
Purpose
A study of tolododekin alfa (also known as ANK-101) administered in combination with an anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibody in participants with advanced or metastatic non-small cell lung cancer (NSCLC). Cohort A will enroll participants who have progressed on prior standard of care treatment with an anti-PD-1/PD-L1 antibody and a platinum-based chemotherapy regimen. Cohort B will enroll participants who are treatment-naïve for locally advanced or metastatic NSCLC.
Condition
- Non Small Cell Lung Cancer
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Have confirmed locally advanced or metastatic NSCLC 2. Thyroid-stimulating hormone (TSH) within normal limits 3. Have measurable disease per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) 4. Eastern Cooperative Oncology Group performance status (ECOG PS) 0 to 1 5. Have a life expectancy > 12 weeks 6. Have baseline electrocardiogram (ECG) without evidence of acute ischemia or prolonged QT interval 7. Heterosexually active women of childbearing potential (WOCBP) must agree to use highly effective methods of contraception 8. Male participants who are not sterile must commit to the use of a reliable method of birth control or abstinence 9. Human immunodeficiency virus (HIV)-infected participants must be on anti-retroviral therapy (ART) and have well-controlled HIV infection/disease 10. Resolution of all prior anticancer therapy toxicities prior to C1D1. 11. Willingness to provide fresh tumor biopsy specimens 12. Capable of understanding and complying with protocol requirements 13. Provides written informed consent for the study
Exclusion Criteria
- Cohort A only: Participants with toxic effects to manage adverse events from previous treatment with immunotherapy 2. Cohort B only: Prior therapy with an immune checkpoint inhibitor. 3. Have known EGFR or ALK mutations 4. Have had prior treatment with recombinant interleukin-12 (IL-12) 5. Have received short-term systemic therapy with immunosuppressive agents prior to C1D1 6. Have active autoimmune disease or medical conditions requiring chronic steroid or other immunosuppressive therapy prior to C1D1 7. Have received live vaccines prior to C1D1 8. Have primary or acquired immunodeficient states 9. Female participant who is pregnant or breastfeeding 10. Have a history of allogeneic tissue/solid organ transplant 11. Has active hepatitis B virus (HBV) or hepatitis C virus (HCV). 12. HIV-infected participants with a history of Kaposi sarcoma and/or Multicentric Castleman Disease 13. Have known active central nervous system metastases 14. Have congestive heart failure, active coronary artery disease, unevaluated new onset angina, unstable angina, or clinically significant cardiac arrhythmias. 15. Have uncontrolled bleeding disorders prior to C1D1 16. Participants on coumadin (warfarin), due to potential for increased bleeding risk associated with surgery 17. History of noninfectious pneumonitis 18. Cohort A only: History of allergy to protein-based therapies, history of any significant drug allergy, or known allergies, hypersensitivity, or intolerance to cetrelimab excipients OR Cohort B only: Hypersensitivity to any component of the anti-PD-1/PD-L1 antibody selected as standard of care 19. Have other systemic conditions or organ abnormalities that may interfere with the conduct of the study 20. Have any acute or chronic psychiatric problems or substance abuse disorder that make the participant unsuitable for participation
Study Design
- Phase
- Phase 1
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Cohort A |
Participants will receive up to 8 cycles of tolododekin alfa in combination with cetrelimab given for up to 1 year |
|
|
Experimental Cohort B |
Participants will receive up to 8 cycles of tolododekin alfa in combination with the Investigator's choice of a Food and Drug Administration (FDA)-approved anti-PD-1/PD-L1 antibody given according to the FDA-approved label |
|
Recruiting Locations
Vanderbilt University
Nashville, Tennessee 37232
Nashville, Tennessee 37232
More Details
- Status
- Recruiting
- Sponsor
- Ankyra Therapeutics, Inc