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Thank you for your interest in Vanderbilt research! Taking part in research is one way to be part of tomorrow’s health care discoveries. Vanderbilt is always looking for volunteers just like you so that our researchers can better understand how to prevent, diagnose, and treat diseases. Everyone is needed. Both healthy volunteers and people with health conditions can help us answer important questions that impact the health of our communities. Ready to start searching for a study?
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Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic an1
Long COVID
Sars-CoV-2 Infection
Coronavirus Infections
COVID-19
The overarching goal of this study is to determine if baricitinib, as compared to
placebo, will improve neurocognitive function, along with measures of physical function,
quality of life, post-exertional malaise, effect of breathlessness on daily activities,
post-COVID-19 symptom burden, and biomar1 expand
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomarkers of inflammation and viral measures, in participants with Long COVID. Type: Interventional Start Date: Oct 2024 |
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Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS
Post-Acute COVID-19 Syndrome
Postural Tachycardia Syndrome (POTS)
SARS CoV 2 Infection
Long COVID19
Long COVID is defined by a range of symptoms affecting multiple organs that persist for
more than three months following an acute SARS-CoV-2 infection. Approximately 7% of
individuals who recover from SARS-Cov-2 infection develop Long COVID.
Long COVID Postural Orthostatic Tachycardia Syndrome (LC1 expand
Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection. Approximately 7% of individuals who recover from SARS-Cov-2 infection develop Long COVID. Long COVID Postural Orthostatic Tachycardia Syndrome (LCPOTS) symptoms include fatigue, exercise intolerance, orthostatic intolerance, syncope, and heightened orthostatic tachycardia. Research has found that decreased parasympathetic activity in LCPOTS increases the production of highly immunogenic neoantigens Isolevuglandins (IsoLG-adducts). IsoLG-adducts induce formation of circulating monocyte/T cell complexes(doublets) leading to the persistent and unresolved immune response that continues after the initial infection. The purpose of the this research, is to study the effects of 2-hydroxybenzylamine (2-HOBA), an Iso-LG-adduct scavenger, its effects in immune markers and compare it with Placebo Type: Interventional Start Date: Dec 2025 |
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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Childr1
Coronavirus Infection (COVID-19)
Pulmonary Arterial Hypertension
Urinary Tract Infections in Children
Hypertension
Pain
The study investigators are interested in learning more about how drugs, that are given
to children by their health care provider, act in the bodies of children and young adults
in hopes to find the most safe and effective dose for children. The primary objective of
this study is to evaluate the PK1 expand
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider. Type: Observational Start Date: Mar 2020 |