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Thank you for your interest in Vanderbilt research! Taking part in research is one way to be part of tomorrow’s health care discoveries. Vanderbilt is always looking for volunteers just like you so that our researchers can better understand how to prevent, diagnose, and treat diseases. Everyone is needed. Both healthy volunteers and people with health conditions can help us answer important questions that impact the health of our communities. Ready to start searching for a study?
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ACTIV-6: COVID-19 Study of Repurposed Medications
Covid19
The purpose of this study is to evaluate the effectiveness of repurposed medications (study
drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19.
Participants will receive either study drug or placebo. They will self-report any new or... expand
The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19. Participants will receive either study drug or placebo. They will self-report any new or worsening symptoms or medical events they may experience while taking study drug or placebo. This study is intended to be all remote with no in person visits, unless the study team feels it is in the best interest of a participant to see them in person. Type: Interventional Start Date: Jun 2021 |
Novel Experimental COVID-19 Therapies Affecting Host Response
COVID-19
SARS-CoV-2 Infection
Coronavirus Infection
The overarching goal of the Master Protocol is to find effective strategies for inpatient
management of patients with COVID-19. Therapeutic goals for patients hospitalized for
COVID-19 include hastening recovery and preventing progression to critical illness,
multiorgan failure,... expand
The overarching goal of the Master Protocol is to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing progression to critical illness, multiorgan failure, or death. Our objective is to determine whether modulating the host tissue response improves clinical outcomes among patients with COVID-19. Type: Interventional Start Date: Jul 2021 |
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19
Covid19
This study looks at the safety and effectiveness of different drugs in treating COVID-19 in
people who have been hospitalized with the infection and who have acute respiratory failure.
Participants in the study will be treated with either a study drug plus current standard of... expand
This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo plus current SOC. Type: Interventional Start Date: Apr 2021 |
A Study of Rivaroxaban to Reduce the Risk of Major Venous and Arterial Thrombotic Events, Hospitalization...
Coronavirus Disease 2019 (COVID-19)
The purpose of this study is to evaluate whether rivaroxaban reduces the risk of a composite
endpoint of major venous and arterial thrombotic events, all-cause hospitalization, and
all-cause mortality compared with placebo in outpatients with acute, symptomatic Coronavirus... expand
The purpose of this study is to evaluate whether rivaroxaban reduces the risk of a composite endpoint of major venous and arterial thrombotic events, all-cause hospitalization, and all-cause mortality compared with placebo in outpatients with acute, symptomatic Coronavirus Disease 2019 (COVID-19) Infection. Type: Interventional Start Date: Aug 2020 |
"CHANGE COVID-19 Severity"
COVID-19 Infection
We are conducting an investigator-initiated, single center, blinded, placebo-controlled,
randomized clinical trial evaluating magnesium citrate combined with a probiotic for the
treatment of adults hospitalized with COVID-19.
expand
We are conducting an investigator-initiated, single center, blinded, placebo-controlled, randomized clinical trial evaluating magnesium citrate combined with a probiotic for the treatment of adults hospitalized with COVID-19. Type: Interventional Start Date: Nov 2021 |
Cognitive Training in Survivors of Covid-19: A Randomized Trial
Covid19
Cognitive Impairment
Preliminary evidence suggests that cognitive impairment is a common outcome experienced by
individuals surviving Covid-19 (1-5). Cognitive impairment following Covid-19 which leads to
critical illness is not surprising and perhaps even expected. However, significant cognitive... expand
Preliminary evidence suggests that cognitive impairment is a common outcome experienced by individuals surviving Covid-19 (1-5). Cognitive impairment following Covid-19 which leads to critical illness is not surprising and perhaps even expected. However, significant cognitive deficits appear to be common even among individuals testing positive for Covid-19 who were never hospitalized. Questions exist regarding the mechanisms of the aforementioned cognitive impairment. The association between COVID-19 and brain dysfunction is not surprising since SARS-CoV has been found in the brain and because Coronaviridaes (CoVs) have been associated with central nervous system (CNS) diseases such as acute viral encephalopathy, acute disseminated encephalomyelitis, and multiple sclerosis (6-11).The possible brain entry routes for CoVs include either direct intranasal access to the brain via olfactory nerves or indirect access by crossing the blood-brain barrier (BBB) via hematogenous or lymphatic spread (9). Type: Interventional Start Date: Aug 2021 |
Post Acute Sequelae of COVID-19
Covid19
Sars-CoV-2 Infection
Dyspnea Caused by 2019-nCoV
COVID-19 Acute Respiratory Distress Syndrome
Pulmonary Fibrosis
COVID-19, a novel coronavirus, has caused widespread mortality and morbidity since it emerged
in 2019. There is ongoing research and growing literature describing severe acute respiratory
syndrome (SARS-COV-2). There is a growing population of individuals who have recovered from... expand
COVID-19, a novel coronavirus, has caused widespread mortality and morbidity since it emerged in 2019. There is ongoing research and growing literature describing severe acute respiratory syndrome (SARS-COV-2). There is a growing population of individuals who have recovered from acute SARS-COV-2 infection. The long-term effects of COVID-19 are unknown. There are growing reports of sequelae after acute SARS-CoV-2 not limited to fatigue, dyspnea, reactive airway disease, organizing pneumonia, pulmonary fibrosis, pulmonary hypertension, pulmonary emboli, and tracheal disease. The incidence and natural history of these findings is unstudied. Type: Observational [Patient Registry] Start Date: Aug 2021 |
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis
Covid19
A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of
antithrombotic strategies in patients with COVID-19 following hospital discharge
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A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge Type: Interventional Start Date: Feb 2021 |
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children...
Coronavirus Infection (COVID-19)
Pulmonary Arterial Hypertension
Urinary Tract Infections in Children
Hypertension
Pain
The study investigators are interested in learning more about how drugs, that are given to
children by their health care provider, act in the bodies of children and young adults in
hopes to find the most safe and effective dose for children. The primary objective of this
study... expand
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider. Type: Observational Start Date: Mar 2020 |