Vanderbilt Clinical Trials

Genetics of Appendix Cancer Study

Purpose

The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.

Conditions

Appendix Cancer
Appendiceal Cancer
Appendiceal Neoplasms
Appendiceal Mucinous Neoplasm
Appendiceal Adenocarcinoma
Appendiceal Carcinoid Tumor
Appendiceal Neoplasm Malignant Secondary
Appendix Adenocarcinoma
Appendix Mucinous Neoplasm
Appendix Tumor
Appendix Cancer Metastatic
Appendix NET
Low-Grade Appendix Mucinous Neoplasm
High Grade Appendix Mucinous Neoplasm
High Grade Appendix Mucinous Adenocarcinoma

Eligibility

Eligible Ages: Over 18 Years
Eligible Genders: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

GAP Social - Known diagnosis of appendix cancer in the United States - Mentally and physically able to consent and participate in the study GAP Vanderbilt - Known diagnosis of appendix cancer - Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study - Mentally and physically able to consent and participate in the study GAP Parent - Biological parents (mother and/or father) of individuals actively participating in the GAP Study - Residing in the United States - Mentally and physically able to consent and participate in the study

Exclusion Criteria

Women pregnant at the time of consent - Prisoners - Unable to provide informed consent - Unable to read, write, or complete questionnaires in English

Study Design

Phase
Study Type: Observational
Observational Model: Cohort
Time Perspective: Prospective

Arm Groups

Arm	Description	Assigned Intervention
GAP Social	Individuals ages 18+ years with an appendix cancer diagnosis in the United States.	Genetic: Genetic profiling Whole exome sequencing Other: Retrospective tissue procurement Collection of archived fixed-formalin, paraffin-embedded (FFPE) primary appendix tumor tissues that were previously removed
GAP Vanderbilt	Individuals ages 18+ years with an appendix cancer diagnosis seen at Vanderbilt.	Genetic: Genetic profiling Whole exome sequencing Other: Retrospective tissue procurement Collection of archived fixed-formalin, paraffin-embedded (FFPE) primary appendix tumor tissues that were previously removed
GAP Parent	Biological parents of active GAP (Social and Vanderbilt) Study participants.	Genetic: Genetic profiling Whole exome sequencing

Recruiting Locations

Vanderbilt-Ingram Cancer Center
Nashville, Tennessee 37232

Contact:
GAP Study Coordinator (Rebecca B.)
615-936-8544
gapcancerstudy@vumc.org

More Details

Status: Recruiting
Sponsor: Andreana Holowatyj, PhD, MSCI

Study Contact

GAP Study Coordinator (Rebecca B.)
615-936-8544
gapcancerstudy@vumc.org

Detailed Description

The Genetics of Appendix Cancer (GAP) Study aims to analyze hereditary factors, tumor characteristics and clinical features/outcomes among adults diagnosed with appendix cancer and their biological parents. Patients are recruited at any time after a diagnosis of appendix cancer and followed for up to 6 years after study enrollment. This cohort is enriched by robust biospecimens and data collections.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.